- SENS Research Foundation - develop, promote, and ensure widespread access to therapies that cure and prevent the diseases and disabilities of aging
- Forever Healthy - private, non-profit initiative with the mission to enable people to vastly extend their healthy lifespan, based in Karlsruhe, Germany.
- Rejuvenation Now - identify potential rejuvenation therapies and systematically evaluates them on their risks, benefits, procedures and potential application
- Maximizing Health - holistically review the world’s leading medical knowledge on various health-related topics and turn it into actionable information to empower informed decisions about health and well-being.
- Undoing Aging - conference in Berlin, Germany
- Long Long Life
- Lifespan.io - articles, interviews. LEAF is a 501(c)(3) non-profit organization dedicated to promoting increased healthy human lifespan through fiscally sponsoring longevity research projects, and raising awareness regarding the societal benefits of life extension.
- The Rejuvenation Roadmap - compile the most promising therapies and technologies in development and chart their progress in one easy to read format
- Peter Attia, MD - strategies and tactics to increase lifespan, healthspan, and well-being, and optimize cognitive, physical, and emotional health
- Josh Mitteldorf - author of 2 aging books and agingadvice.org, evolutionary biology, Ph.D. in astrophysics.
- aginganalytics - world’s premier provider of industry analytics on the topics of Longevity, Precision Preventive Medicine and Economics of Aging. In 2014, it successfully predicted the boom in industry development and financing rounds that occurred in 2017-2018, three years in advance.
- Collection of Longevity Links:
- fightaging - on the right side of the page: First Steps, Root Causes, Required Reading, Non-Profit Initiatives, The Longevity Industry, Benefiting from Medical Research, Objections Answered, Blogs of Interest. All under CC BY 4.0 license.
- anti-agingfirewalls - by Vince Giuliano, 90 years old (in 2019). Computer scientiest, focused now on longevity.
|Damage type||Maintenance approach|
|Cell loss, cell atrophy||Replace, using stem cells|
|Division-obsessed cells||Reinforce, using telomere control|
|Death-resistant cells||Remove, using suicide genes etc|
|Mitochondrial mutations||Reinforce, using backup copies|
|Intracellular waste products||Remove, using foreign enzymes|
|Extracellular waste products||Remove, using immune system|
|Extracellular matrix stiffening||Repair, using crosslink-breakers|
to be clarified
See the suggestions in Maximizing Health by Forever Healthy.
Exercise Advice by Forever Healthy
Source: Physical Activity
- We need to build muscle to reach peak health
- Advantages: most efficient way to lose weight, better cardio, strengthens the cardio-vascular system,
- The most effective training is the one that depletes all types of muscle fibers in the shortest amount of time.
- Gym Training:
- Body Weight Training
- Recommended Book: You Are Your Own Gym
Exercise Advice by Peter Attia
Do a lot of consistent preparatory work in the decades prior your 70s.
- >10mins/day, >1h/week
- Dynamic neuromuscular stabilization (DNS)
- Postural Restoration Institute (PRI)
- The teacher matter a lot!
- Static stability and dynamic stability
- 3x 1h sessions/week
- with weights or body weight
- Aerobic efficiency (Zone 2)
- min 2h-3h/week
- Zone 2
- still able to hold a conversation while training
- stimulates stimulate Type 1 muscle fibers -> mitochondrial growth and function -> ability to utilize fat and preserve glycogen AND increase lactate clearance capacity
- Anaerobic work (Zone 5)
- high intensity, HIIT
- not much of it, incorporate into regular activity
- exercise every single day
Other Exercise Notes
Healthy at 100, John Robbins:
“What if there was a pill that would keep you fit and lean as you aged, while protecting your heart and bones? What if it was as good for your brain as for your body, if it made you stronger, more confident, less susceptible to depression? What if it improved your sleep, mood, and memory and reduced your risk of cancer, all while adding life to your years and years to your life? A great number of studies have found that exercise can provide all these benefits and more, even for people who begin late in life. We are learning that much of the physical decline that older people suffer stems not from age but from simple disuse.”
- “The researchers found that the frequency of colds among people who exercised five or more days a week was up to 46 percent less than that of people who were largely sedentary—that is, who exercised only one day or less per week.” Super Immunity by JOEL FUHRMAN
- aerobics not only releases the endorphins that can combat a down mood but also promotes the growth of the brain (Dan Siegel’s Mindsight)
Michael Lustgarten, PhD, Interview
Eight years of an increased average life expectancy came from people who exercise for 30 minutes a day. And this isn’t, strenuous weightlifting. This was as limited as just walking for 30 minutes a day.
- Should train for:
- Maintaince of muscle mass
- Joint integrity
- Functional Movement
- two dietary components, apigenin and quercetin to increase NAD
- Apigenin: Parsley, 40g every other day
- Quercetin: Dill, Red Onion
For Biological Age:
- Optimizing Biological Age